تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Evaluation of the Cytogenetic Status and DNA Integrity of Human Lymphocytes after Exposure to an Aqueous Extract of Rhazya Stricta Leaves in Vitro
Evaluation of the Cytogenetic Status and DNA Integrity of Human Lymphocytes after Exposure to an Aqueous Extract of Rhazya Stricta Leaves in Vitro
 
الموضوع : علوم الأحياء 
لغة الوثيقة : الانجليزية 
المستخلص : Human lymphocyte culture cells were treated with three different concentrations (6, 12 and 24 g/liter) of R. stricta aqueous leaf extract. Samples were collected at three different intervals (24, 48 and 72h) for each concentration. Following each treatment, cell samples were subjected to cytogenetic as well as comet test assays. The cytogenetic assay revealed a significant decrease in mitotic index that was inversely proportional with concentration and exposure time. Many aberrations, including high percentage of interphase, increased micronuclei, viscosity, colchicines metaphase and two nuclei-cells were detected. Microscopic observation showed necrosis of most of the treated cells at all used concentrations, an indicative possibility of anticancer activity. Comet test detected DNA lesions that were proportionally concentration- and exposure time-dependent too. The present data strongly suggest that the aqueous extract of the R. stricta leaves has mutagenic, clastogenic and possibly anticancer activities on human lymphocytes in vitro. 
ردمد : 1816-157X 
اسم الدورية : Journal of Applied Sciences Research 
المجلد : 5 
العدد : 8 
سنة النشر : 2009 هـ
2009 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Sunday, March 21, 2010 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
نبيه عبد الرحمن باعشنBaeshen, Nabih Abdulrahmanباحثدكتوراه 
جمال صابر محمد صابرSabir, Jamal S.MباحثدكتوراهJsabir@Kau.edu.sa
صلاح الدين محمد ابو عباAbo-Aba, Salah al-Din Mohammedباحثدكتوراه 
سمير قاريQari, Sameer باحث  

الملفات

اسم الملفالنوعالوصف
 26117.pdf pdfAbstract

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